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    • Oligonucleotides: modified DNA, RNA, and peptide-hybrid sequences

    • Natural and modified oligonucleotides can be drawn, stored, and searched in ChemDraw and related databases.
    • Author: Jesse Gordon , Company: PerkinElmer Informatics
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  • Natural and modified oligonucleotides can be drawn, stored, and searched in ChemDraw and related databases. This paper defines a "monomer library" for common modified nucleotides and peptides, which you can download for your use in ChemDraw, and which are discussed under the following topics:

    • Methyl Ribonucleotides
    • Phosphorothioate linkages
    • LNA Ribonucleotides
    • Anti-sense nucleotides
    • Beta- and D-amino acids
    • Hybrid sequences and chimeric sequences

    ChemDraw's oligonucleotides (and all biopolymers) are of unlimited length, and always include atom-by-atom underlying chemical structures. The structures can be displayed ("expanded"), or kept "collapsed" as monomer abbreviations. In either case, ChemDraw can perform chemical analysis (atom count, Molecular Weight calculation, etc.), and the structures can be stored in ChemFinder or other ChemDraw-associated databases. ChemDraw has several methods for representing oligonucleotides:

    • Sequence tool: .....

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