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    • Ambiguous nucleotides and non-specific proteins: Variable residues in ChemBioDraw sequences

    • Author: Jesse Gordon , Company: PerkinElmer Informatics
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  • Molecular biologists often need to represent nucleotides and peptides based on incomplete information. And sometimes nature is non-specific in translating DNA into proteins. ChemBioDraw can represent ambiguous peptides and nucleotides, with the capability to register such sequences, and to expand the non-specific structures into multiple unambiguous chemical structures.

    This article presents a monomer library, in the form of ChemBioDraw nicknames, which you can install and use in both peptide and nucleotide sequences. This article is organized into the following sections:

    • Defining ambiguous nucleotide codes and side-chain nicknames
    • Ambiguous nucleotide monomer library for DNA and RNA
    • Defining non-specific amino acid monomers
    • Defining non-proteinogenic amino acid monomers
    • Using newly-defined .....

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