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    • Faster insights and better science in the search for desperately needed new therapies

    • In a previous post  we noted the increasing importance of biologics as therapeutic agents, with 37% of the drugs approved by the FDA in 2017 being biologic entities. A recent article in Chemical & Engineering News (June 4, 2018, pp 28-33) focused on activities in immuno-oncology, where biologic checkpoint inhibitors are being tested in combination with other immunotherapies: there are currently ca. 250 small molecule- and antibody-based immunotherapies in clinical studies, and > 1100 clinical trials in 2017 combined a checkpoint inhibitor with another ...

    • Rapid, Incisive Data Analysis for Lead Discovery

    • In a previous post we commiserated with drug discovery scientists and their IT colleagues in their daily struggles to deal with the ever-increasing research data deluge. We then attempted to ease their pain by exploring modern informatics tools and applications that guide them to rapidly and intelligently identify, locate, search, extract and organize tractable sets of relevant data (internal or external, structured or unstructured, small molecule or biologic) for detailed analysis and visualization. This current post moves to the improvements that are needed in the ...

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